Answer: What the meaning of the word mesoamerica is that in Greek it's Middle Americas and it associates itself with the modern day areas of parts of Belize, parts of Colombia, northern Costa Rica, parts of El Salvador, parts of Guatemala, parts of Honduras, and central and southern Mexico, also parts of Nicaragua. For thousands of years ago, this area was populated by groups such as the Aztec, Maya, Olmec, and Toltec, also Zapotec peoples.