Given:
Point R: (5, 1)
Midpoint M: (1, 4)
Since it's been mentioned that point M is a midpoint. Finding S, the graph should look like this:
Let's determine the translation from point M to R, because the opposite of it will be the translation to get point S.
From Point M to R:
Therefore, getting to the endpoint S, it will have 4 units to the left and 3 units upward.
We get,
Therefore, the missing endpoint is: -3, 7