Answer: 54080
Since the first number cannot be 0 or 1, there would be only 8 possible numbers for the first number. For the second number, we can now have all 10 numbers.
The number of different combinations of numbers would then be:

Then, for the first letter, we have 26 possible letters, as well as the second letter. The number of different combinations of letters would then be:

So, for a license plate that has 2 numbers and 2 letters, where the first number cannot be 0 or 1, there would be:
