D.
The slope of a line means the increase in y for each unitary increase in x:

If the slope is equal to -0.1625, that means if x increases 1 unit, y will decrease by 0.1625 units.
E.
Using x = 3 in the regression equation, we have:

So the estimated GPA is 3.23.
F.
If r is the value of the standard deviation, therefore r² is the variance:

The variance is the average of the squared difference from each point to the mean, and it measures the average of how much each point differs from the mean.