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Which of the following mutations will cause the least damage to the resulting protein?

a. An insertion at the end of the DNA strand.
b. A deletion at the beginning of a DNA strand.
c. A silent substitution at the beginning of the DNA strand.
d. A missense substitution at the end of the DNA strand.

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Answer: The correct answer is C. A silent substitution at the beginning of the DNA strand.

Step-by-step explanation: A silent substitution/mutation has the least effect on a protein because changes to the DNA base often don't affect the sequence of amino acids in the protein. They do not affect the structure or function of the protein as a result.

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