Question

Which of the following mutations will cause the most damage to the resulting protein?

a. An insertion at the end of the DNA strand.
b. A deletion at the beginning of a DNA strand.
c. A silent substitution at the beginning of the DNA strand.
d. A missense substitution at the end of the DNA strand.

Answer 1

Answer: The correct answer is C. A silent substitution at the beginning of the DNA strand.

Step-by-step explanation: A silent substitution/mutation has the least effect on a protein because changes to the DNA base often don't affect the sequence of amino acids in the protein. As a result, they do not affect the structure or function of the protein and do not create a frame-shift.