Answer:
The isolation of America's meant people didn't have immunity, and the high population density.
Step-by-step explanation:
Diseases in different parts of the world vary, so when a disease first enters a country it means that 1. There's usually no vacines in that country yet and 2. The populations immune system has never came across these diseases before so can catch the illness easier.
With a high population density it allows communicable diseases to be passed on faster