Question

leptin is secreted by adipose tissue to slow the appetite. despite this, many people continue to gain weight. why does this mechanism not always work?

Answer 1

Step-by-step explanation:

Obese people have unusually high levels of leptin. This is because in some obese people, the brain does not respond to leptin, so they keep eating despite adequate (or excessive) fat stores, a concept known as 'leptin resistance'. This causes the fat cells to produce even more leptin.