Answer:
$2,081.00
Explanation:
You want to know how much more $4,622.00 is than $2,541.00.
How much more
The wording "how much more" usually refers to the difference, the value that results from subtracting the smaller number from the larger one.
In this case, that is ...
$4622 -2541 = $2081
The first place winner got $2,081.00 more than the runner-up.
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Additional comment
The wording "how many times more" usually refers to the ratio, the value that results from dividing the larger number by the smaller one.