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10 votes
10 votes
some genetic disorders decrease susceptibility to malaria. what is an example of a genetic disorder that has this effect?

User Hebe
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1 Answer

19 votes
19 votes
Perhaps related to the high frequency of diseases related to genes conferring resistance to malaria is that many of resistance variants, such as G6PD deficiency, the thalassaemias, sickle-cell anaemia, and ovalocytosis, are “loss of function” mutants and lead to reduced expression or altered gene product.
User Mark Davies
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