Answer:
(-1, -4)
Explanation:
y = -x is the 45° diagonal through the origin from top left to bottom right.
a reflection across that line brings anything that is in quadrant 1 (x and y are positive) to quadrant 3 (x and y are negative) like this point. and vice versa.
points in quadrant 2 stay in quadrant 2, points in quadrant 4 stay in quadrant 4.
but in every case x and y are exchanged and both signs are flipped like (-1, 2) turns into (-2, 1).
or for our point : (4, 1) turns into (-1, -4)