Answer:
The most significant impact, even though it was deadly, would be the diseases that were transmitted through the Columbian exchange from the Old World to the New World. Native Americans that were on this land had never been exposed to these diseases before, so they had no way to get around the diseases that were transmitted from the people that had settled to the New World. It had been one of the primary reasons why the Native population had been completely demolished and had been colonized on.
Step-by-step explanation: