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immature t cells called – undergo development in the . once there, the immature t cells travel outward to the and progressively move back inward to the throughout their development.

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T cells are derived from haematopoietic stem cells that are found in the bone marrow. The progenitors of these cells migrate to and colonise the thymus. The developing progenitors within the thymus, also known as thymocytes, undergo a series of maturation steps that can be identified based on the expression of different cell surface markers.

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