Answer:
2 - 4 + 6 x 8 = 46
Explanation:
We know that John can use each operation only once. Therefore, addition could be the first, second, or third operation from left to right. Likewise, subtraction could be the first, second, or third operation, and multiplication could be the first, second, or third operation. Recall that the multiplication must be the first operation to be performed because of the order of operations. Thus, the possible combinations are
2 + 4 - 6 x 8 = -42,
2 + 4 x 6 - 8 = 18,
2 - 4 + 6 x 8 = 46,
2 - 4 x 6 + 8 = -14,
2 x 4 + 6 - 8 = 6,
2 x 4 - 6 + 8 = 10.
Now, we can see that the highest possible number that John can obtain is 2 - 4 + 6 x 8 = 46.