The correct answer to this open question is the following.
Based on the source titled "A Voyage to South America" and my prior knowledge, I can say that the impact of colonization in the New World was that Spanish people married Native South American Indians -in this case, Inca people- and they bred a new race called "Mestizos."
These Mestizos were born from a Spanish father/mother and a Native Indian father/mother.
This also happened in Mesoamerica with the Aztec civilization people and the Spanish conquerors.
This was part of the consequences of the Spanish conquest in Mesoamerica and South America, and the later foundation of New Spain.
Let's not forget that one of the negative consequences of the Spanish presence in America was that they brought many mortal diseases such as chickenpox, malaria, smallpox, cholera, and influenza. These diseases almost wipe out 80% of Native American people.