Answer:
1, 3, 5, 6
Step-by-step explanation:
1: A mutation can change the protein shape, but will not necessarily always change the protein shape.
3: Mutations can be neutral if they have no effect on the organisms survival.
5: Mutations can be harmful if they decrease the odds of survival of an organism.
6: Mutations can be beneficial. Evolution starts off with a beneficial mutation. Traits that increase an organisms odds of survival are beneficial mutations.
I hope this helps :0).