When and by whom was Nineveh destroyed? A. In 783 B.C. By Jeroboam II B. In 654 B.C. By Alexander the Great C. In 612 B.C. By Cyaxerxes, King of the Medes, Nabopolassar, King of Babylon, and Umman Manda, King of the Scythians D. In 543 B.C. By The Byzantine Empire