Answer: "European demands for Fur, which had a major effect on American Indians near the St. Lawrence River. The fur trade was based on good relationships between the First Nations peoples and the European traders.
Explanation: Perhaps the single greatest impact of European colonization on the North American environment was the introduction of disease. Microbes to which native inhabitants had no immunity caused sickness and death everywhere Europeans settled. new diseases. Native peoples of America had no immunity to the diseases that European explorers and colonists brought with them. Diseases such as smallpox, influenza, measles, and even chicken pox proved deadly to American Indians.