Answer:
Complement
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The Complement System: Overview
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Major component of Innate Immune System
Consists of over 30 proteins, which participate in a tightly regulated cascade-like activation process.
Protects host from pathogenic microorganims, contributes to immune complex regulation & is an important link between the innate & adaptive immune systems.
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3 Major Outcomes of Complement Activation
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1. Stimulation of inflammatory reactions via release proinflammatory mediators, which induce chemotaxis of leukocytes (leading to microbe destruction) & inflammation
2. Opsonization of pathogens by depositing fragments of complement proteins on the pathogens, making them more susceptible to phagocytosis
3. Complement-Mediated Cytolysis, via formation of a Membrane Attack Complex, which can insert itself into bacterial membrane & cause osmotic lysis
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Alternative Pathway Steps
Lectin Pathway Activation
Classical Pathway Activation
Terms in this set (67)
The Complement System: Overview
Major component of Innate Immune System
Consists of over 30 proteins, which participate in a tightly regulated cascade-like activation process.
Protects host from pathogenic microorganims, contributes to immune complex regulation & is an important link between the innate & adaptive immune systems.
3 Major Outcomes of Complement Activation
1. Stimulation of inflammatory reactions via release proinflammatory mediators, which induce chemotaxis of leukocytes (leading to microbe destruction) & inflammation
2. Opsonization of pathogens by depositing fragments of complement proteins on the pathogens, making them more susceptible to phagocytosis
3. Complement-Mediated Cytolysis, via formation of a Membrane Attack Complex, which can insert itself into bacterial membrane & cause osmotic lysis
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