Answer:Accumulation of bile salts: Bile salts are normally excreted by the liver into the bile, which aids in the digestion and absorption of fats in the small intestine. When there is a blockage in the bile ducts, bile salts can build up in the bloodstream, leading to higher concentrations of bile salts in the skin. This excess of bile salts can irritate the nerve endings in the skin and cause itching.
Accumulation of bilirubin: Bilirubin is a waste product that is normally excreted by the liver into the bile and then eliminated from the body through the stool. In obstructive jaundice, bilirubin can accumulate in the bloodstream because it cannot be properly excreted. Elevated levels of bilirubin in the skin can lead to a yellowing of the skin and eyes (jaundice) as well as itching.
Inflammatory and immune responses: The buildup of bile and bilirubin in the bloodstream can trigger inflammatory and immune responses in the body. This can cause the release of various chemical mediators that can sensitize nerve endings in the skin, making them more prone to itching.
Skin dryness and irritation: Jaundice can also lead to changes in the composition and function of the skin, making it drier and more prone to irritation. Dry skin can be itchy, and the combination of dryness and elevated bilirubin levels can contribute to itching in individuals with obstructive jaundice.
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