Answer:
Roanoke and diseases
Step-by-step explanation:
The difficulties of settling in America for the English are illustrated by the lost settlement at Roanoke, which was organized by Walter Raleigh in the late sixteenth century. Spanish explorers like Juan Ponce de León and Hernán de Soto are the groundwork for later English colonization because they spread diseases that devastated native tribes and broke up the great chiefdoms of the Southeast.
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