Question

A 10-month-old asymptomatic infant presents with a RUQ mass. Work-up reveals a normocytic anemia, elevated urinary HVA/VMA, and a large heterogeneous mass with scant calcifications on CT. A bone marrow biopsy is performed. Which of the following histologic findings on bone marrow biopsy is most consistent with your suspected diagnosis?

A. Sheets of lymphocytes with interspersed macrophages
B. Small round blue cells with dense nuclei forming small rosettes
C. Hypersegmented neutrophils
D. Stacks of RBCs
E. Enlarged cells with intranuclear inclusion bodies

Answer 1

The clinical presentation described is concerning for neuroblastoma, a pediatric malignancy. The most consistent histologic finding on bone marrow biopsy in neuroblastoma is:

B. Small round blue cells with dense nuclei forming small rosettes