Final answer:
Giant Granules are seen in Chediak Higashi due to a genetic mutation that disrupts the normal fusion process of lysosomes, causing them to cluster into large granules and impairing the immune cell's ability to fight off infections.
Step-by-step explanation:
In patients with Chediak Higashi, you see Giant Granules due to a particular genetic mutation that affects the normal process of lysosomal trafficking.
Usually, lysosomes (small, enzyme-filled organelles in cells) merge with phagosomes to form phagolysosomes, destroying engulfed bacteria. In Chediak Higashi, this fusion is disrupted, so the lysosomes cluster together into giant granules.
This faulty fusion process also impairs the immune cell's ability to attack invading pathogens, leading to increased susceptibility to infections.
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