The abnormal blood work result most closely associated with a diagnosis of multiple myeloma is:
a. Low glomerular filtration rate and high calcium levels
Multiple myeloma is a type of cancer that affects plasma cells in the bone marrow. The cancerous plasma cells can crowd out healthy blood-forming cells in the bone marrow and lead to various abnormalities in blood work. In multiple myeloma, there is often kidney damage, which can result in a low glomerular filtration rate (GFR). Additionally, the cancer can lead to high levels of calcium in the blood due to the release of calcium from bone tissue.
So, option (a) reflects the blood work abnormalities commonly associated with multiple myeloma.