Final answer:
The first English colony in North America to fail due to the disappearance of all its settlers was the Roanoke Colony, also identified as The Lost Colony.
Step-by-step explanation:
The first English colony in North America that failed when all its settlers disappeared is known as the Roanoke Colony. Established in 1585 by Sir Walter Raleigh on Roanoke Island, present-day Dare County, North Carolina, this colony is infamous for its sudden and unexplained disappearance, a mystery often referred to as The Lost Colony. Nothing definitive was found to explain what happened to the colonists, and they left behind only one cryptic clue - the word 'CROATOAN' carved into a post.
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