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what is the minimum number of alleles that is required for a genetic disorder to be expressed: X-linked recessive disorder in a female

User Orbitum
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Females can get an X-linked recessive disorder, but this is very rare. An abnormal gene on the X chromosome from each parent would be required since a female has two X chromosomes.

Genes on the X chromosome can be recessive or dominant. Their expression in females and males is not the same. Genes on the Y chromosome do not exactly pair up with the genes on the X chromosome. X-linked recessive genes are expressed in females only if there are two copies of the gene (one on each X chromosome).

Cystic fibrosis, sickle cell disease. X-linked dominant. X-linked dominant disorders are caused by variants in genes on the X chromosome. In males (who have only one X chromosome), a variant in the only copy of the gene in each cell causes the disorder.

User Troyseph
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