Question

Of the following methods, which can NOT be used to separate a mixture of enantiomers? A fractional distillation (separation based on a difference in boiling points) B chiral resolving agents C chiral column chromatography D All of the above methods can be used to separate enantiomers.

Answer 1

The method that can NOT be used to separate a mixture of enantiomers is chiral column chromatography.

Step-by-step explanation:

The method that can NOT be used to separate a mixture of enantiomers is C. chiral column chromatography.

Chiral column chromatography is a separation technique that involves using a stationary phase with chiral properties to separate enantiomers. The stationary phase contains a chiral resolving agent, which interacts differently with the enantiomers based on their specific chirality. This allows for the separation of the enantiomers. However, if a mixture of enantiomers is already separated, chiral column chromatography would not be needed, as it is a method used specifically for separating enantiomers.

Answer 2

Chiral resolving agents cannot be used to separate a mixture of enantiomers.

Step-by-step explanation:

Of the given methods, chiral resolving agents cannot be used to separate a mixture of enantiomers. Chiral resolving agents are substances that selectively react with one enantiomer to form a diastereomeric product, which can then be separated from the remaining enantiomer. This method relies on the difference in reactivity between the enantiomers and is not applicable to all cases.