Answer:
The statements that are true are:
-Infectious disease was the number one killer of Native Americans after the arrival of the Spanish.
-To meet the European desire for free labor, millions of Africans were kidnapped and shipped to the Americas via the Middle Passage.
-When Christopher Columbus landed in the Americas, he found the land largely unpopulated.
-Spain and Portugal colonized most of North America. Spanish missionaries came to the Americas to convert the American Indians to Christianity.
-Europeans brought flour, apples, and horses to the Americas.
-Under the system of encomienda, Spanish conquistadors profited from the forced labor of Native Americans.