The regions in question are the Southern colonies, Middle colonies, and New England colonies.
The Southern colonies, known for plantation agriculture, had the most common presence of slavery.
The Middle colonies, which included Pennsylvania populated by Quakers, commonly opposed slavery.
The New England colonies, such as Massachusetts, were where slavery was first legally recognized.
You can remember it this way: Slavery was most common in the South, opposed by Quakers in the Middle, and first recognized in New England.