Conclusion: False
Explanation: Phase II drug metabolism reactions are not exclusively oxidative reactions. While oxidative reactions are indeed a common type of Phase II reaction, they are not the only type. Phase II reactions involve the conjugation of a drug molecule with an endogenous molecule, such as glucuronic acid, sulfate, or amino acids, to make the drug more water-soluble and easier to eliminate from the body.
These conjugation reactions can involve various enzymes, such as UDP-glucuronosyltransferases, sulfotransferases, and glutathione transferases. Each enzyme is responsible for a specific type of conjugation reaction. For example, UDP-glucuronosyltransferases add glucuronic acid to the drug molecule, while sulfotransferases add a sulfate group.
Other types of Phase II reactions include acetylation, methylation, and amino acid conjugation. Acetylation involves the addition of an acetyl group to the drug molecule, methylation adds a methyl group, and amino acid conjugation involves the attachment of an amino acid to the drug molecule.
In summary, Phase II drug metabolism reactions are not solely oxidative reactions. They involve a variety of conjugation reactions that make the drug more water-soluble for elimination from the body.