Answer: C. How much power to give the central government while preventing tyranny
Explanation: The core dispute between the Federalists and Anti-Federalists during the formation of the US constitution was over the allocation of power – how much power should be given to the central government and how much should be left to the states. Federalists argued for a strong central government, while Anti-Federalists feared that this could lead to tyranny and favored stronger state governments to prevent this. Hence, the idea 'how much power to give the central government while preventing tyranny' was at the core of their dispute.