Answer:
Enslaved people tended to work on large farms in both the middle and southern colonies.
Step-by-step explanation:
Of the given options, the most accurate comparison of slavery in the middle colonies and the southern colonies in the 1600s is:
Enslaved people tended to work on large farms in both the middle and southern colonies.
During the 1600s, both the middle colonies (such as New York, New Jersey, Pennsylvania, and Delaware) and the southern colonies (such as Virginia, Maryland, North Carolina, South Carolina, and Georgia) relied on enslaved labor for their agricultural production. Enslaved people were commonly used on large farms, including plantations, in both regions. This option reflects the historical reality of slavery during that time period.