Answer:
Impaired oxygen supply (hypoxia) or reduced blood flow (ischemia) to the brain causes significant metabolic changes in neuronal and non-neural cells. I
Step-by-step explanation:
Hypoxia develops acutely in CO poisoning, which displaces oxygen from hemoglobin. Global ischemia is worse than hypoxia, hypoglycemia, and seizures because, in addition to causing energy failure, it results in accumulation of lactic acid and other toxic metabolites that are normally removed by the circulation.