The drug bicuculline is used in electrophysiology studies to isolate glutamatergic neurotransmission. It works by binding to the GABA recognition site on GABAA receptors, which prevents GABA from activating the channel.
A. GABA binding to the GABAA receptor results in ____________ of the membrane.
B. Bicuculline binding to the GABAA receptor results in __________________ of the membrane.
C. Bicuculline is often used on brain slices from rodents containing hippocampal or cortical neurons in models of epilepsy. Epilepsy is defined as a rush of electrical activity in the brain. Briefly explain why neurons treated with bicuculline would be a good model of epilepsy.