Question

chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized ra

Answer 1

Because chronic lithium, carbamazepine and valproate decrease the turnover of arachidonic acid (AA) but not docosahexaenoic acid (DHA) in brain phospholipids of the awake rat, they tested if topiramate would produce similar results.