First, I would start with asking "do you know why you were prescribed the little yellow pill?" to clarify Mrs. Clark's understanding of her initial medication education, and then based on her answer I can know where improvements are needed.
Then, I would ask Mrs. Clark "how long after you stopped taking the medication did this swelling in your legs start?" This, atop the improvements on medication education given from the previous question, emphasizes a correlation to the patient that hydrochlorothiazide is a blood pressure medication that decreases edema and if not taken (even when feeling better) means the swelling can return.
Because of the increase in blood pressure as evidenced by Mrs. Clark's vital signs, I would now ask "how have you been feeling lately since being off the medication? Has your heartbeat felt faster? Have you been more anxious?" because symptoms of hypertension such as anxiety and tachycardia could returned due to discontinuation. Again, addressing it could emphasize a correlation to the patient: if you stop the med, all of this returns.
Since Mrs. Clark is stating that she is experiencing nocturia (increased nighttime urination) when taking the medication, the next question I would ask is "when during the day were you taking the little yellow pill?" This is because I suspect Mrs. Clark is taking the medication closer to bedtime rather than administering it in the morning -- hydrochlorothiazide is known to cause a disruption of the sleep cycle and her body may be trying to eliminate more often to decrease the fluid volume that is causing her edema.
Just as an assessment question associated with the edema, I would ask "has your fluid intake increased recently?" to also explain the nocturia.
To help Mrs. Clark increase her medication compliance, I would ask if she eats breakfast at around the same time everyday, and if yes, ask if she thinks she could take her medication with her morning meal. Reiterate that the medication should be administered in the morning and it should be taken with food or milk so that GI upset does not occur. You can also tell her, this way will not have her up all night going to the restroom. Any other patient teaching can happen when the patient agrees. After, you can ask Mrs. Clark what the medication is and when she says she will take it to return-demonstrate understanding.