Answer:
Based on the provided information, the two immune cell subsets that are implicated as important regulators of HIV replication and the rate of disease progression are:
CD4+ T-helper cells (also known as CD4+ T-cells or helper T-cells): These cells play a crucial role in coordinating immune responses by activating and directing other immune cells. CD4+ T-helper cells are the primary target of HIV, and the virus specifically infects and destroys them. The loss of CD4+ T-helper cells leads to a weakened immune system, making individuals more susceptible to opportunistic infections and disease progression.
CD8+ cytotoxic T-lymphocytes (also known as CD8+ T-cells or cytotoxic T-cells): CD8+ T-cells are a type of immune cell that plays a critical role in directly killing virus-infected cells. They recognize and target cells displaying viral antigens, including HIV-infected cells, leading to their destruction. CD8+ T-cells are important for controlling viral replication and limiting the spread of HIV within the body.
Step-by-step explanation:
These two immune cell subsets, CD4+ T-helper cells and CD8+ cytotoxic T-lymphocytes, are intricately involved in the immune response against HIV and are crucial for regulating viral replication and the rate of disease progression.