Answer:
There are several reasons why a protein with the correct amino acid sequence might not be functional . Here are two possible reasons:
Protein folding: In order to function properly, many proteins need to fold into a specific conformation or shape. Even if a protein has the correct sequence of amino acids, it may not fold correctly on its own. To fold properly, proteins often require the assistance of chaperone molecules or other proteins. If a protein fails to fold correctly, it may be vulnerable to degradation or aggregation, which can lead to disease. In other cases, a protein may fold into the correct shape but then undergo changes in conformation later on due to certain environmental conditions, such as changes in temperature or pH, that can lead to loss of function.
Post-translational modifications: After a protein is synthesized, it can undergo various modifications that can affect its function. For example, many proteins require specific molecules to be added to them, such as lipids or sugars, in order to become active or to localize to specific parts of the cell. In other cases, proteins may need to be cleaved into smaller fragments in order to become active or to be transported to specific cellular compartments. Any error during these processes can lead to a protein that is non-functional or with a different function than what was intended.
Step-by-step explanation: