Answer: the person who does not have the mutation in TFX would be expected to have higher expression of gene X compared to the person with the mutation.
Step-by-step explanation:
In this scenario, where a mutation in the transcription factor TFX prevents it from binding to the enhancer of gene X, we can expect that the person who does not have the mutation will have higher expression of gene X compared to the person who carries the mutation.
The reason for this expectation is that the binding of transcription factors to enhancer regions plays a crucial role in gene expression regulation. Enhancers are DNA sequences that are involved in controlling the activity of nearby genes. When a transcription factor binds to the enhancer of a gene, it facilitates the recruitment of other proteins and complexes necessary for gene transcription, ultimately leading to higher expression of that gene.
In this case, the TFX transcription factor normally binds to the enhancer of gene X, likely promoting its transcription and resulting in higher expression levels. However, due to the identified mutation in TFX, the transcription factor is unable to bind to its consensus sequence on the enhancer. As a result, the recruitment of necessary factors for gene expression may be hindered, leading to lower expression of gene X in the individual with the mutation.
Conversely, the person who does not have the mutation in TFX would have an intact transcription factor that can bind to the enhancer, facilitating the recruitment of transcriptional machinery and promoting higher expression of gene X.
Therefore, we would expect the person without the TFX mutation to have higher expression of gene X compared to the person with the mutation.