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Chapter One argues that drug use has positive as well as negative consequences for humans. Considering the advantages and disadvantages of using different drugs, would you allow the use of a drug that currently is illegal for the most part, such as cocaine, marijuana, or heroin? Why or why not?

User Applechief
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Answer: A substantial body of research has accumulated over several decades and transformed our understanding of substance use and its effects on the brain. This knowledge has opened the door to new ways of thinking about prevention and treatment of substance use disorders.

This chapter describes the neurobiological framework underlying substance use and why some people transition from using or misusing alcohol or drugs to a substance use disorder—including its most severe form, addiction. The chapter explains how these substances produce changes in brain structure and function that promote and sustain addiction and contribute to relapse. The chapter also addresses similarities and differences in how the various classes of addictive substances affect the brain and behavior and provides a brief overview of key factors that influence risk for substance use disorders.

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