Question

Preindopril mechanism of action ?

Answer 1

inhibition of ACE activity.

Step-by-step explanation:

The mechanism through which perindoprilat lowers blood pressure. ACE is a peptidyl dipeptidase that catalyzes conversion of the inactive decapepetide, angiotensin i, to the vasoconstrictor, angiotensin ii.

Answer 2

Perindopril, and generally any medication ending in the suffix -pril, is an angiotensin-converting enzyme (ACE) inhibitor, meaning its mechanism of action is to block the conversion of blood hormone angiotensin 1 to vasoconstricting blood hormone angiotension 2, as well as increase increase plasma levels of enzyme renin and reduce levels of aldosterone, with the goal of causing systemic vasodilation which leads to a decrease in blood pressure in those with hypertension (HTN) and decreased risk of death from cardiovascular events in patients with coronary artery disease (CAD).