D. the Guale
In 1597, Spanish missionaries in Georgia experienced a violent rebellion perpetrated by the Guale. The Guale were Native American tribes who inhabited the coastal regions of present-day Georgia. The Spanish missionaries, as part of their efforts to colonize and convert indigenous populations, faced resistance from the Guale people. This rebellion was a response to the Spanish missionaries' attempts to impose their religious and cultural practices on the Guale and to assert control over their land. The Guale revolted against the Spanish presence, leading to a violent conflict between the two groups.