Question

state some reasons immune self-tolerance may fail and give examples of the resulting diseases (see 21.6b ""autoimmune diseases"" in your text)

Answer 1

Step-by-step explanation:

Immune self-tolerance can fail for various reasons, resulting in autoimmune diseases. Some factors include genetic susceptibility, environmental triggers, loss of tolerance mechanisms, molecular mimicry, and dysregulation of regulatory T cells. Examples of autoimmune diseases include systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes, multiple sclerosis (MS), and autoimmune polyendocrine syndrome type 1 (APS-1).