Answer & Explanation:
Based on the symptoms described, the underlying problem and pattern of symptoms is suggestive of intermittent claudication. Intermittent claudication refers to muscle pain or cramping that occurs during physical activity, typically in the calf muscles, and subsides with rest. It is often a result of inadequate blood supply to the affected muscles.
The problem causing this man's symptoms could be located in the arterial system supplying the leg muscles. The most common site of arterial narrowing or blockage leading to intermittent claudication is the peripheral arteries, particularly the femoral and popliteal arteries in the leg.
Other tissues in his limb that could be affected include the skin and subcutaneous tissues. Reduced blood flow to these tissues can manifest as hair loss, thinning skin, coolness, and delayed wound healing.
The doctor would need to record the arterial pulses in the affected limb, specifically the dorsalis pedis pulse on the top of the foot and the posterior tibial pulse behind the medial ankle. These pulses can provide information about the adequacy of blood flow to the lower limb.
Two metabolic anomalies that could be important in this case are atherosclerosis and oxidative stress. Atherosclerosis is the gradual buildup of plaque within the arteries, narrowing the arterial lumen and restricting blood flow. Oxidative stress, caused by an imbalance between free radicals and antioxidants, can contribute to arterial damage and dysfunction. Both these factors can contribute to the development of peripheral arterial disease and intermittent claudication.