If you plot the point (12,16), you could draw a right triangle where the hypotenuse is the radius.
so 12^2+16^2 =r^2 (the hypotenuse)
144 + 256 = r^2
400 = r^2
20 = r
the equation of this circle would be x^2 + y^2 = 20^2
or x^2 + y^2 = 400
see screenshot!