Answer: Natural disasters, especially floods.
Explanation: Natural disasters (such as drought, flood, tornado, hurricane, wildfire, etc.......) can cause imbalances in certain regions because a region can be prone to be at risk of certain natural disasters.
Example: Chile is known to have the most powerful and dangerous earthquakes. This can be bad for the economy and people, because the economy/government has to pay money to clean up collapsed buildings, and the people are at risk of dying
Natural disasters especially affect economies, the same as people. Take floods and droughts for example: If a region or area receives too little flood, they'll have a bad agriculture industry. The same is for a flood, but the crops are overflooded and the crops (one by one) will die out. But, the crops have a chance of surviving a flood, rather than a drought.