All three scenarios can cause the usual OLS t-statistics to be invalid.
Heteroskedasticity affects the efficiency of the standard errors, high correlation between independent variables can lead to multicollinearity issues, and omitting important variables can introduce bias and affect the validity of hypothesis tests.
When heteroskedasticity is present, the OLS estimator remains unbiased, but the estimated standard errors are incorrect. As a result, the calculated t-statistics may not follow the standard t-distribution under the null hypothesis, leading to unreliable hypothesis tests.
Perfect multicollinearity makes it impossible to obtain unique coefficient estimates because the variance of the estimates becomes infinite. In such cases, OLS cannot be applied, and the t-statistics for the affected coefficients are undefined.