Question

What is one reason that lead intoxication causes hypochromic anemia?

Answer 1

Chronic lead poisoning inhibits the ability to produce hemoglobin by interfering with enzymatic steps in the heme synthesis pathway and diminishes red blood cells, thereby increasing risk of anemia [15]. The absorption of lead can cause iron deficiency and may further cause anemia.

Answer 2

Lead causes anemia by impairing heme synthesis and increasing the rate of red blood cell destruction. On the other hand, it is also possible that iron deficiency, which is a proven cause of anemia, leads to increase in the absorption of lead in the body, resulting in high BLL.