Question

in developing countries, the polio vaccine is administered as a live, attenuated virus. if the virus co-circulates with coxsackie virus, the two can

Answer 1

Interfere with each other's replication and the vaccine's effectiveness may be reduced.

Answer 2

interact and potentially cause a condition known as vaccine-associated paralytic poliomyelitis (VAPP).

Step-by-step explanation:

This is because both poliovirus and coxsackievirus belong to the same family of viruses, called enteroviruses, and can cause similar symptoms. When a person receives the live attenuated polio vaccine, the weakened virus in the vaccine can sometimes mutate back to a more virulent form and cause disease. In rare cases, the co-circulation of coxsackievirus and the live attenuated polio virus in the community can increase the risk of this mutation occurring, leading to VAPP.

To reduce the risk of VAPP, some countries have switched to using inactivated polio vaccine (IPV) instead of live attenuated vaccine. IPV does not contain live virus and therefore cannot cause VAPP, but it requires multiple doses and is generally more expensive than the live attenuated vaccine. Ultimately, the decision of which vaccine to use depends on a variety of factors, including the prevalence of wild polio virus in the region and the cost-effectiveness of each vaccine.