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What drugs interact with TCAs?

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There are several drugs that can interact with TCAs (Tricyclic Antidepressants). Here are a few examples:

1. MAOIs (Monoamine Oxidase Inhibitors): Taking TCAs and MAOIs together can cause dangerous increases in blood pressure, hyperpyrexia, seizures, and other severe side effects.

2. SSRIs (Selective Serotonin Reuptake Inhibitors): Combining TCAs and SSRIs can increase the risk of serotonin syndrome, which is a potentially life-threatening condition that can cause rapid heartbeat, high blood pressure, seizures, hyperthermia, and other serious symptoms.

3. Anticholinergics: Taking TCAs with other anticholinergic drugs (such as atropine, benztropine, or scopolamine) can cause side effects such as dry mouth, constipation, and blurred vision.

4. CNS Depressants: Using TCAs with other CNS depressant drugs (such as alcohol or benzodiazepines) can increase the risk of side effects such as dizziness, drowsiness, and impaired coordination.

It is important to always inform your doctor or pharmacist about all the medications you are taking, to avoid any potential drug interactions.
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